Beilstein J. Org. Chem.2014,10, 692–700, doi:10.3762/bjoc.10.62
azomethine ylides, generated in situ from the parent furo[3,2-h]quinoliniums/phenanthroliums, in presence of a copper(II) chloride–phenanthroline catalytic system. The methodology combines general applicability with high yields.
Keywords: copper(II) chloride–phenanthroline; 1,3-dipolar cycloaddition; furo
after an extensive screening, we found copper(II) chloride–phenanthroline as the best catalytic pair for this purpose. Herein we wish to present the results of our recent synthetic efforts to synthesize a series of unique pentacyclic pyrrolo[3′,4′:3,4]pyrrolo[1,2-a]furoquinolines/phenanthrolines using
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Graphical Abstract
Scheme 1:
Preparation of maleimide dipolarophiles 4a–c.